12 cases of lactic acidosis associated with metformin reported to CARM since 1977, 2 occurred in the last year and 8 cases had a fatal outcome.. The widespread acceptance of metformin evolved after the realization that lactic acidosis was not a major problem in individuals with normal renal function.. File Format: PDFAdobe Acrobat - View as HTML Compared to its predecessor phenformin, metformin is 20 times less likely to produce lactic acidosis. Metformin NEST-CAM does not increase peripheral lactate. There are also other questions about the of metformin and OCT1 and OCT2.

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